Tc-HMPAO SPECT in persistent post-concussion syndrome after mild head injury comparison with MRI/CT

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Abstract
The purposes of this study were 1 to determine the prevalence of abnormal mTc HMPAO SPECT scans in patients suffering persistent post concussive syndrome PPCS after mild closed head injury CHI 2 to compare SPECT with structural neuroimaging MRI and CT in patients with mild CHI and 3 to investigate correlations between SPECT and clinical data obtained from the patient sample neuropsychological testing demographics psychiatric diagnoses Forty three patients were included SPECT was read as abnormal in 53 of patients and showed a total of 37 lesions while MRI was read as abnormal in 9 and CT scan in only 4 6 of patients after mild CHI SPECT appears to be more sensitive in detecting cerebral abnormalities after mild CHI especially in patients with PPCS symptoms than either CT or MRI No statistically significant relationship was found between SPECT scan abnormalities and age past psychiatric history history of substance abuse or history of multiple CHI Education level did differ between patients with normal and abnormal SPECT Current neuropsychiatric symptoms did not seem to have any impact on the results of SPECT scan

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