New Directions in the Treatment of Acute Lymphoblastic Leukemia in Children

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Abstract
The era of effective chemotherapy for acute lymphoblastic leukemia in children began almost four decades ago with an article in the Journal in which Sydney Farber and his coworkers1 described their results with aminopterin. In the two decades that followed, other drugs were introduced and found to be effective as single agents and even more effective in combination. By the beginning of the 1970s, combined drug therapy with central nervous system prophylaxis was resulting in long-term disease-free survival and apparent cure in more than half the cases of acute lymphoblastic leukemia in children.2 For his important contributions to this accomplishment, . . .