HPV 16 E7 oncoprotein induces expression of a 110 kDa heat shock protein
- 11 September 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 371 (3) , 214-218
- https://doi.org/10.1016/0014-5793(95)00884-c
Abstract
Heat shock protein genes are induced by various kinds of stress. Besides stress, the heat shock family gene hsp70 has been shown to be induced by growth-stimulating agents such as the DNA virus oncoproteins and serum. Here, we report cloning of a novel cDNA that encodes a 100 kDa heat shock protein-related polypeptide as a human papillomavirus oncoprotein E7-inducible gene. E7 induces expression of this heat shock protein at the level of RNA synthesis. Moreover, the induction of this heat shock protein-mRNA was dependent on the conserved region 2 of the E7 protein, which is essential for binding to the proteins of the retinoblastoma family.Keywords
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