Possible Linkage between the Major Histocompatibility Complex and the Immune Response to Factor VIII in Classic Haemophilia
- 1 November 1977
- journal article
- research article
- Published by Wiley in Vox Sanguinis
- Vol. 33 (5) , 270-272
- https://doi.org/10.1111/j.1423-0410.1977.tb04473.x
Abstract
The pattern of HLA segregation was analyzed in 10 sibships of haemophilia A patients, each of which included 1 or 2 haemophilic brothers with an antibody to factor VIII. The observed HLA distribution is suggestive of a linkage between the major histocompatibility complex and a gene responsible for immune response to isologous factor VIII.This publication has 8 references indexed in Scilit:
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