METABOLIC APPROACH TO EVALUATION OF PERIPHERAL VASCULAR-DISEASE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 144  (1) , 51-57
Abstract
Patients (35) with occlusive disease of the arteries underwent metabolic studies. The arteriovenous differences of lactate, glucose and O2 varied with the severity of the ischemic process, as assessed clinically. Lactate release and glucose extraction were significantly different from control values of patients with rest pain or with ischemic gangrene, while values in patients with claudication were comparable with those in the control group. Percutaneous muscle surface pH measurements, which reflect lactate release, decreased directly with diminished perfusion. Metabolic assessment of arterial occlusive disease may prove to be a useful clinical approach.