Synthesis of Some Substituted Pyrroline-1-Oxides by Catalytic Hydrogenation of Aliphatic Gamma-Nitrocarbonyi Compounds
- 1 September 1986
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 16 (11) , 1377-1385
- https://doi.org/10.1080/00397918608056386
Abstract
Various pyrroline-1-oxides were prepared by the catalytic hydrogenation of appropriately substituted gamma-nitrocarbonyl compounds. Initially the reaction affords a mixture of the nitrone and the corresponding hydroxylamine, but copper(II)-catalyzed aerial oxidation readily converts the hydroxylamine to the desired cyclic nitrone. This method was found to be more convenient than the zine-ammonium chloride reduction and the corresponding yields were comparable.Keywords
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