Structure of two human beta-actin-related processed genes one of which is located next to a simple repetitive sequence.
Open Access
- 1 May 1983
- journal article
- research article
- Published by Springer Nature in The EMBO Journal
- Vol. 2 (5) , 757-761
- https://doi.org/10.1002/j.1460-2075.1983.tb01496.x
Abstract
From a human gene library we have isolated and sequenced a beta‐actin‐like pseudogene, H beta Ac‐psi 2, which lacks intervening sequences and contains several mutations resulting in frame‐shifts, stop codons and in a departure from the known beta‐actin protein sequence. We have also extended our sequence work on the intronless human beta‐actin‐related pseudogene H beta Ac‐psi 1 described previously and we find that both genes are processed genes ending in a poly(dA) tract and flanked by direct repeats. The gene H beta Ac‐psi 2 is preceded by a 230‐bp region in which the simple sequence 5′‐GAAA‐3′ is repeated greater than 40 times. This satellite‐like sequence is highly repetitive in the human genome.This publication has 32 references indexed in Scilit:
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