Adrenergic Receptors: Classification, ligand binding and molecular properties

Publisher Website
Google Scholar
Abstract
The interaction of catecholamines and drugs with adrenergic receptors leads to a set of biochemical reactions which ultimately results in a physiological response. A brief review is given of the classification of adrenergic receptors into subtypes and the use of ligand binding techniques for the identification and characterization of these receptors. Recent advances in the biochemistry of adrenergic receptors are reviewed with special reference to the interaction of the βand α2–receptors with guanine nucleotide regulatory proteins and adenylate cyclase. The role of calcium and phos–phoinositides in the function of the α1–receptor is also discussed.