Bio-Assay of Thyrotropin in Man

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Abstract
The author reviews the history of the subject briefly, then the methods in use, the results in human urine and blood, both normal and pathological, and the possibility of an antagonist to thyrotropin. He states finally, "The lack of sensitivity in present-day bio-assays precludes a wide clinical usefulness for the estimation of thyrotropin in human blood regardless of the investigational value of the methods. Despite the restricted applications of the methods, however, their replacement by a chemical assay does not seem imminent at this time.".