Syntheses of Acyclic Analogs of Didemnin B
- 1 September 1997
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 27 (18) , 3259-3272
- https://doi.org/10.1080/00397919708004186
Abstract
The syntheses of three modified peptide fragments of the cyclodepsipeptide didemnin B are reported. The HIP and isostatine (1st) units of the didemnin B macrocycle were simplified to a Z-alanine residue and the ester linkage (through threonine of the tetrapeptide) was replaced with amide linkages through the amines of glycine, D-alanine and an ethylenediamine linker. The latter permitted the attachment of a N-Me-D-Leu-Pro-Lac moiety to afford analogs 2, 3 and 4 respectively.Keywords
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