EVALUATION OF PRESERVATION DAMAGE AFTER PORCINE LIVER TRANSPLANTATION BY ASSESSMENT OF HEPATIC MICROCIRCULATION
- 1 December 1990
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 50 (6) , 940-942
- https://doi.org/10.1097/00007890-199012000-00007
Abstract
The ischemic damage following liver transplantation (LTX) is predominantly located at the endothelial cell level and is a major cause for a disturbance of microcir-culation. The present study was designed to test the hypothesis that changes in the quality of organ preservation are correlated with changes in microcirculation: 16 pigs underwent LTX, preservation by Bretschneider's HTK-solution (Histidin, Tryptophan, α-Ketoglutarat) complemented by indomethacin (50 μmol/L). Cold ischemia times were 9 hr (n=8) and 18 hr (n=8), respectively. Using the H2-clearance technique, hepatic micro-circulation was measured before, 30 min, and 20 hr after LTX. Normal tissue perfusion was 107±16 ml/100 g/min, at 30 min posttransplantation 91±13 ml/100 g/min in the short-term and 48±7 ml/100 g/min in the long-term preservation group. Whereas no animal of the long-term preservation group survived longer than 8 hr, all animals of the short-term preservation group survived, and tissue perfusion could be measured 20 hr postoperatively (101±19 ml/100 g/min). At 30 min postoperatively, all surviving animals had tissue perfusion rates grater than 70, and all nonsurvivors had values below 60 ml/100 g/min. We conclude therefore that the extent of decrease of microcirculation after LTX may be a useful predictor of organ function and survival.Keywords
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