Catecholamine-Induced Alteration in Sedimentation Behavior of Membrane Bound β-Adrenergic Receptors
- 24 October 1980
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 210 (4468) , 441-443
- https://doi.org/10.1126/science.6254143
Abstract
Incubation of astrocytoma cells with catecholamines results in a decrease in catecholamine-stimulated adenylate cyclase activity and a concomitant alteration in the sedimentation properties of particulate beta-adrenergic receptors. The altered receptors exhibit agonist binding properties similar to those of receptors that are "uncoupled" from adenylate cyclase.Keywords
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