The In Vitro Catabolism of Histamine by Sheep Liver Tissue

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Abstract
Thein vitroinactivation of histamine by the liver of sheep has been examined with the following results: At optimal substrate concentrations liver slices inactivated 178.5±57.4(S.D.) μg histamine diphosphate/g wet weight of tissue/hr. There was no marked difference between the histamine inactivation in liver slices and homogenates.‐Aminoguanidine, a powerful inhibitor of diamine oxidase (E.C. 1.4.3.6.), strongly counteracted the histamine inactivation, indicating that oxidative deamination is the major pathway for histamine inactivatoin in sheep liver tissuein vitro.‐On an average about 1 per cent of added histamine was inactivated by conjugation.‐Inhibition experiments indicated that no significant methylation takes place.‐The average content of preformed histamine in 41 sheep was 24.7±11.1 μg histamine diphosphate/g wet weight of tissue.

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