Preliminary Observations on Absorption and Excretion of Sulfiodizole, a New Long-Acting Sulfonamide

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Abstract
A new antibacterial sulfonamide, (sulfiodizole), was compared with sulfamethoxazole. Both sulfonamides are fairly rapidly absorbed from the gastrointestinal tract and reached identical maximum plasma peaks 4 hrs. after oral administration, but sulfiodizole shows higher and longer maintained plasma levels in contrast to sulfamethoxazole. The proportion of sulfiodizole in the conjugated form is much smaller than that of sulfamethoxazole. Urinary excretion of sulfiodizole is much slower than that of sulfamethoxazole. However, the proportion of the former sulfonamide in the conjugated form is smaller than that of the latter. Sulfiodizole shows appreciable concentrations in the plasma 48 hrs. after a single oral dose of 2 g, (averaging 3.8 and 3.3 mg/dl total and free drug, respectively). This sulfonamide should be of clinical interest, and further exploration of the chemotherapeutic activities is warranted.

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