Z-DNA-forming sequences are spontaneous deletion hot spots.
- 1 October 1989
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 86 (19) , 7465-7469
- https://doi.org/10.1073/pnas.86.19.7465
Abstract
Z-DNA-forming sequences are shown to elicit a biological response in Escherichia coli. Plasmids containing sequences capable of adopting the Z conformation (GC and CA/GT) are shown to be hot spots for spontaneous deletions. All the deletions involve an even number of base pairs. The distribution of the deletion events shows that the process ends when the Z-DNA-forming sequence has been reduced to a size no longer capable of adopting the Z conformation at natural superhelical density.This publication has 29 references indexed in Scilit:
- A two-state conformational equilibrium for alternating (A-T)n sequences in negatively supercoiled DNAJournal of Molecular Biology, 1987
- Use of site-specific recombination as a probe of DNA structure and metabolism in vivoJournal of Molecular Biology, 1987
- Bacterial chromatin: A new twist to an old storyNature, 1986
- Construction of frameshift mutation hot spots within the tetracycline resistance gene of pBR322Biochimie, 1985
- Left-handed DNA and the synaptic pairing reaction promoted by ustilago recl proteinCell, 1985
- Transcriptional block caused by a negative supercoiling induced structural change in an alternating CG sequenceCell, 1984
- Carcinogen-induced mutation spectrum in wild-type, uvrA and umuC strains of Escherichia coliJournal of Molecular Biology, 1984
- DNA binding spectrum of the carcinogen N-acetoxy-N-2-acetylaminofluorene significantly differs from the mutation spectrumJournal of Molecular Biology, 1984
- Evidence of cruciform structures in superhelical DNA provided by two‐dimensional gel electrophoresisFEBS Letters, 1983
- Hot spots of frameshift mutations induced by the ultimate carcinogen N- acetoxy-N-2-acetylaminofluoreneNature, 1981