Genetic background of autoimmune hepatitis in Japan
Open Access
- 19 October 2010
- journal article
- Published by Springer Nature in The Esophagus
- Vol. 46 (S1) , 42-47
- https://doi.org/10.1007/s00535-010-0333-2
Abstract
Autoimmune hepatitis (AIH) is an organ-specific autoimmune disease characterized by chronic inflammation of the liver. Several studies from ethnically different countries have clarified that the genetic predisposition to type 1 AIH is linked mainly to human leukocyte antigen (HLA)-class II genes. Recently, molecular analysis using polymerase chain reaction (PCR)-based DNA typing has revealed that susceptibility to type 1 AIH is primarily associated with the HLA class II DRB1 locus, which encodes a polymorphic β chain of the HLA-DR antigen. However, additional susceptibility genes (either HLA or non-HLA) and/or environmental factors may also contribute to the development of type 1 AIH; in Japanese type 1 AIH patients, although the most influential gene in disease susceptibility is HLA-DRB1*04:05, several other genes have been identified as being involved in AIH pathogenesis or resistance and are the currently the focus of single nucleotide polymorphism analysis.Keywords
This publication has 42 references indexed in Scilit:
- The most severe forms of type I autoimmune hepatitis are associated with genetically determined levels of TGF-β1Clinical Immunology, 2010
- Association of cytotoxic T-lymphocyte antigen 4 gene polymorphisms with type 1 autoimmune hepatitis in JapaneseHepatology Research, 2008
- Human leukocyte antigen DR status and clinical features in Japanese patients with type 1 autoimmune hepatitisHepatology Research, 2007
- A genomewide DNA microsatellite association study of Japanese patients with autoimmune hepatitis type 1Hepatology, 2007
- Genetic analysis of the HLA region of Japanese patients with type 1 autoimmune hepatitisJournal of Hepatology, 2005
- Clinical distinctions and pathogenic implications of type 1 autoimmune hepatitis in Brazil and the United StatesJournal of Hepatology, 2002
- Autoimmune hepatitis in Brazilian patients is not linked to tumor necrosis factor α polymorphisms at position −308Journal of Hepatology, 2001
- Present status of autoimmune hepatitis in Japan - correlating the characteristics with international criteria in an area with a high rate of HCV infectionJournal of Hepatology, 1997
- Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis†Hepatology, 1994
- Susceptibility to autoimmune chronic active hepatitis: Human leukocyte antigens DR4 and A1-B8-DR3 are independent risk factorsHepatology, 1991