Muscarinic-activated K+ current in bovine aortic endothelial cells.
- 1 June 1988
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation Research
- Vol. 62 (6) , 1059-1064
- https://doi.org/10.1161/01.res.62.6.1059
Abstract
Isolated, cultured arterial endothelial cells express an acetylcholine (ACh)-activated K+ current in addition to an inward rectifier current whose conductance is unaffected by ACh. The cholinergic K+ current is specifically blocked by atropine (1 microM) and shows single saturation kinetics with ACh (half-maximal stimulation 51 nM ACh). Unlike the cardiac muscarinic receptor-gated K+ channel, its stimulation appears independent of a pertussis toxin-sensitive GTP-binding protein. Activation of the endothelial muscarinic K+ current resulting in hyperpolarization may represent an initial component of the vasodilatory effect of ACh.This publication has 24 references indexed in Scilit:
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