Regioselectivity in the thermal 1,2-cycloaddition of benzocyclobutenes to 3,4-dihydroisoquinolines
- 1 January 1974
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 1712-1714
- https://doi.org/10.1039/p19740001712
Abstract
Thermolysis of 1,2-dihydro-4,5-dimethoxybenzocyclobuten-1-ol (7a) in the presence of 3,4-dihydro-6,7-dimethyoxyisoquinoline (8), followed by reduction of the product with sodium borohydride, gave the berbine alkaloid xylopinine (2a). Regioselectivity in the cycloaddition of benzocyclobutenes to the 3,4-dihydroisoquinoline system is described.Keywords
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