Compatibility Study Between Atenolol and Tablet Excipients Using Differential Scanning Calorimetry
- 1 January 1990
- journal article
- research article
- Published by Taylor & Francis in Drug Development and Industrial Pharmacy
- Vol. 16 (12) , 1945-1954
- https://doi.org/10.3109/03639049009028349
Abstract
In order to improve the formulation of atenolol the physico-chemical compatibility between the drug and various excipients, commonly used in tablet manufacturing, was studied with the aid of Differential Scanning Calorimetry (DSC). Using this method, it was found that atenolol is compatible with starch, Sta-Rx®, Primojel®, Avicel PH®, Ac-Di-Sol®, cross-linked PVP, magnesium stearate, calcium sulphate dihydrate, dicalcium phosphate and icing sugar. Interactions of atenolol with PVP, lactose and the lubricant stearic acid were found, although it cannot be conlusively stated that interaction incompatibilities will occur during storage at room temperature.This publication has 6 references indexed in Scilit:
- Drug-drug incompatibility in the solid state: kinetic interpretation, modelling and predictionInternational Journal of Pharmaceutics, 1984
- Detectors in chromatographyAnalytical Proceedings including Analytical Communications, 1982
- Application of Differential Thermal Analysis to Compatibility and Stability Problems in Penicillin-Stearic Acid MixturesJournal of Pharmaceutical Sciences, 1969
- Interactions Between Pharmaceutical Compounds by Thermal MethodsJournal of Pharmaceutical Sciences, 1969
- Diffuse Reflectance Studies of Solid–Solid InteractionsJournal of Pharmaceutical Sciences, 1965
- Comparative Evaluation of Dextrose and Spray-Dried Lactose in Direct Compression SystemsJournal of Pharmaceutical Sciences, 1965