Increased levels of plasma thrombomodulin are associated with vascular and all-cause mortality in patients on long-term anticoagulant treatment
Open Access
- 1 October 1996
- journal article
- research article
- Published by Oxford University Press (OUP) in European Heart Journal
- Vol. 17 (10) , 1503-1505
- https://doi.org/10.1093/oxfordjournals.eurheartj.a014713
Abstract
The aim of the study was to test if plasma levels of thrombomodulin could predict mortality in 209 patients on long-term anticoagulant treatment followed up for 38 years. The thrombomodulin level was 60·9 ± 29·8 μg. 1−1 for all 45 patients who died and 60·5 ± 30·5 .μg. 1−1 for the 38 vascular deaths, compared to 52·3 ± 20·7 μg. 1−1 for the 164 survivors. We found that, in Cox regression analyses, all-cause (P=0·025) and vascular mortality (P=0·042) was significantly and independently associated with increased levels of thrombomodulin. The level of plasma thrombomodulin can predict all-cause and vascular mortality in patients on long-term anticoagulant treatment. (Eur Heart J 1996; 17: 1503–1505)Keywords
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