Synthesis and antiarrhythmic activity of 2-dialkylaminoalkyl-9-phenyl-1H-indeno[2,1-c]pyridine derivatives

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Abstract
Some dihydro- and hexahydro-2-dialkylaminoalkyl-9-phenyl-1H-indeno[2,1-c]pyridines were prepared and found to possess significant antiarrhythmic activity. Hydrogenation of the dihydro compounds produced the all-cis-hexahydro isomers which were consistently active in three assays against induced ventricular arrhythmias in rabbits. The H9,H9a-trans isomers, which were obtained by basic equilibration of the cis isomers, were less effective.