Isolation and Characterization of Mutants of Escherichia coli K12 Resistant to the New Aminoglycoside Antibiotic, Amikacin
- 1 June 1976
- journal article
- research article
- Published by Microbiology Society in Journal of General Microbiology
- Vol. 94 (2) , 389-394
- https://doi.org/10.1099/00221287-94-2-389
Abstract
Spontaneous mutants of E. coli K12 that are resistant to the new aminoglycoside antibiotic, amikacin, were isolated. These mutants have simultaneously acqured cross-resistance to kanamycin, gentamicin and neomycin but not to streptomycin or spectinomycin. Sensitivity of the mutant strains to the non-aminoglycoside antibiotics, ampicillin, tetracycline and polymyxin, was unaffected. The mutation responsible for amikacin resistance was mapped by [phage] P1 transduction and was tightly linked to strA, distal with respect to spcA and aroE.Keywords
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