Cross‐Reactions of HL‐A Antibodies. V. Relationship between the Human HL‐A11 and Chimpanzee ChW‐11 Specificities

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Abstract
In direct cross‐species typing, the chimpanzee ChW‐11 and human HL‐A11 leukocyte groups seem identical since ChW‐11 antisera detect HL‐A11 on human cells and human HL‐A11 sera recognize the ChW‐11 specificity on chimpanzee cells. However, when using quantitative platelet absorption and pH gradient elution it was possible to distinguish these specificities serologically; homologous antigen‐antibody binding avidities were greater than those between species.The use of quantitative absorption followed by cross‐species typing is discussed also as a means of identifying heterogeneity among certain leukocyte specificities. These techniques were used to characterize cross‐reacting chimpanzee leukocyte specificities, ChW‐11 and ChW‐111, which appear to form part of the chimpanzee “LA‐like segregant series” and to compare these specificities with the human HL‐A11 determinant(s).