L‐serine obtained by methanol addition in batch crystallization

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Abstract
The solubility of L‐serine in water was measured as a function of temperature, and the solubility in methanol‐water solutions was determined as a function of temperature and methanol concentration. Solubility in aqueous solutions was found to be a linear function of temperature. Additionally, a statistical design of experiments was used to identify the kinetic variables that influence the purity of L‐serine crystals recovered by batch crystallization. Agitation and the rate at which super‐saturation was generated through cooling and methanol addition were found to influence the methanol content of the recovered crystals. The size of the recovered crystals also was found to depend on agitation and the rate at which methanol was added to the L‐serine mother liquor.