Chemotherapy of Cancer

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Abstract
Antimetabolites Glucose metabolism. Early work by Warburg13 showed that tumor cells possessed a high rate of anerobic glycolysis. He thought that this observation could explain the etiology and pathogenesis of tumors because of the possibility that interference with the respiration of growing cells could result in a mutational change leading to a characteristic form of glycolysis and thence to neoplastic growth. However, during the past ten years, it has become apparent that although there is a high rate of glycolysis in tumor cells, this may not be the major pathway for providing metabolic energy to the cancer cell, and the . . .