Abnormal tau species are produced during Alzheimer's disease neurodegenerating process
- 24 April 1989
- journal article
- Published by Wiley in FEBS Letters
- Vol. 247 (2) , 213-216
- https://doi.org/10.1016/0014-5793(89)81337-7
Abstract
Tau proteins were detected in human brain using two polyclonal antibodies: anti-paired helical filaments and anti-human native tau proteins. Both antisera detected identically the normal set of tau proteins in control brains. Moreover they detected two abnormal tau variants of 64 and 69 kDa exclusively in brain areas showing neurofibrillary tangles and senile plaques. Tau 64 and 69 were abnormally phosphorylated as revealed by the decrease in their molecular mass observed after alkaline phosphatase treatment. Therefore, tau 64 and 69 are specific markers of the neurofibrillary degeneration of the Alzheimer type and might be useful tools for studying the first pathological events that lead to neuronal death.Keywords
This publication has 15 references indexed in Scilit:
- Preferential localization of copper zinc superoxide dismutase in the vulnerable cortical neurons in Alzheimer's diseaseNeuroscience Letters, 1988
- Microtubule-associated polypeptides tau are altered in Alzheimer paired helical filamentsMolecular Brain Research, 1988
- Structural characterization of the core of the paired helical filament of Alzheimer disease.Proceedings of the National Academy of Sciences, 1988
- Alzheimer's disease: A new evidence for common epitopes between microtubule associated protein Tau and paired helical filaments (PHF): Demonstration at the electron microscope level by a double immunogold labellingVirchows Archiv, 1988
- Neocortical morphometry, lesion counts, and choline acetyltransferase levels in the age spectrum of Alzheimer's diseaseNeurology, 1988
- Aluminum and alzheimer's diseaseNeurobiology of Aging, 1986
- Alzheimer's disease: Tau proteins, the promoting factors of microtubule assembly, are major components of paired helical filamentsJournal of the Neurological Sciences, 1986
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984
- Alzheimer paired helical filaments: Bulk isolation, solubility, and protein compositionActa Neuropathologica, 1984
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970