Effect of chemotherapy on survival of craniofacial osteosarcoma: a systematic review of 201 patients.
- 1 January 1997
- journal article
- review article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 15 (1) , 363-367
- https://doi.org/10.1200/jco.1997.15.1.363
Abstract
PURPOSETo evaluate the possible value of chemotherapy in the treatment of craniofacial osteosarcoma (CFOS).DESIGNIn a systematic review, data of 201 patients (age, 36.6 +/- 19.0 years [mean +/- SD]) from 20 uncontrolled series on CFOS indexed in Medline and Excerpta Medica between 1974 and 1994 were pooled; 180 patients had undergone surgery. Various chemotherapy regimens had been given to 71 patients. Radiotherapy was used in 69 patients. All patients had data for overall survival, and 182 had data for disease-free survival analysis. Cumulative survival distributions were estimated by the product-limit method, and a multiple regression analysis was performed.RESULTSPatients' overall and disease-free survival rates were significantly improved by treatment with chemotherapy. This was confirmed for patients with complete surgical removal, as well as for those with incomplete removal of tumor. In a proportional hazards model, complete surgical removal and chemotherapy were independent significant factors for...Keywords
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