DISTRIBUTION OF [131I]α1–24ADRENOCORTICOTROPHIN IN THE INTACT GUINEA-PIG
- 1 April 1971
- journal article
- Published by Bioscientifica in Journal of Endocrinology
- Vol. 49 (4) , 649-658
- https://doi.org/10.1677/joe.0.0490649
Abstract
Intact, unanaesthetized guinea-pigs were injected intravenously with [131I]α1–24adrenocorticotrophin (ACTH) (50–70 ng). The concentrations of radioactivity found in the kidney were considerably higher than in other tissues. There was no evidence for preferential accumulation in the adrenal gland as a whole when compared with 125I-labelled bovine albumin ([125I]BSA), [125I]poly-l-tyrosine and [125I]iodide. The intra-adrenal distribution of 131I radioactivity showed one peak at the border between the zona glomerulosa and the z. fasciculata and another in the z. reticulosa. The intra-adrenal distribution of [125I]BSA and [125I]iodide differed from that of [131I]α1–24ACTH.Keywords
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