SUPPRESSOR CELLS IN TUMOR BEARING MICE AND RATS

  • 1 January 1976
    • journal article
    • editorial
    • Vol. 24  (6) , 371-374
Abstract
Suppressor macrophages in spleens of tumor bearing mice and rats inhibited in vitro reactivity of lymphocytes to T [thymus-derived] and B [bone marrow derived] cell mitogens and to allogeneic cells in the mixed lymphocyte culture. They also inhibited in vitro reactivity against syngeneic tumor cells in the mixed lymphocyte tumor cell interaction and the in vitro generation of secondary cytotoxic effector cells. Similar suppressor cells may play an important role in the general immunosuppression of tumor bearing hosts and in the inability of tumor bearing hosts to effectively reject the tumor. [Phytohemagglutinin, mitomycin C, concanavalin A and bacterial endotoxin were the mitogens used.].

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