Another Retroviral Disease of the Nervous System

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Abstract
ON the basis of studies in animal models it has been known for some time that retroviruses can cause central nervous system infection and chronic neurologic disease. Indeed, one of the prototypic "slow" infections of the brain providing the basis for Sigurdsson's pioneering concept in the 1950s is now known to be caused by a retrovirus, visna virus.1 However, only within the past three years has it been demonstrated that this group of RNA viruses, classified according to their capacity to produce a DNA provirus copy of their genome in the infected cell (reverse transcription), can cause similar diseases in . . .