AN ATTEMPTED REVERSAL OF THALIDOMIDE EMBRYOPATHY IN THE RAT BY GLUTAMINE

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Abstract
Skeletal, cardiovascular, and urethral defects were observed in the 21-day-old offspring of Sprague–Dawley rats following administration of thalidomide (2% of diet) during the entire gestation period. The fetuses of animals which received either l-glutamic acid or l-glutamine (2% of diet each), in addition to thalidomide, showed essentially the same incidence and type of gross defects as those from the thalidomide-treated mothers.The ineffectiveness of these essential growth factors to reduce the embryopathy significantly is interpreted to indicate that they are not predominately involved in the teratogenic action of thalidomide in the rat.