Excretion of Steroid Hormones in Adults

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Abstract
The steroids in faeces from three healthy persons, one woman and two men, were analyzed by gas‐liquid chromatography and gas chromatography‐mass spectrometry. Both C19O2, C19O3, C21O2 and C21O3 steroids were found in the free steroid and in the steroid monosulphate fractions.Incubation of various precursor steroids with intestinal contents recovered from the ileostoma of a colectomized patient demonstrated the presence of intestinal bacterial 16α‐ and 21‐dehydroxylating enzymes. Furthermore, it was shown that a Δ16‐C21 steroid was converted to a 17α‐pregnane derivative and that the side chain of 11β,21‐dihydroxy‐4‐pregnene‐3,20‐dione could be removed by the intestinal bacteria.

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