New suggestions for the physiological role of secretory protein-I.

  • 1 July 1987
    • journal article
    • review article
    • Vol. 2  (4) , 251-5
Abstract
A major endocrine secretory protein of unknown function termed secretory protein-I or, alternatively, chromogranin A, is attracting increasing attention. Because of its abundance and apparently universal presence in endocrine and neuroendocrine cells, many suggestions for a physiological role have been advanced. Recent data provide the first firm bases for some proposed functions that include a regulator of a novel protease capable of converting prohormones to hormones, a hormone precursor, and through its calcium-binding and aggregating properties, a secretory granule condensing protein.

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