EFFECT OF GUANETHIDINE ON METABOLIC RESPONSE TO NORADRENALINE AND COLD RESISTANCE IN WARM-ACCLIMATED RATS
- 1 March 1964
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 42 (2) , 265-267
- https://doi.org/10.1139/y64-029
Abstract
Intraperitoneal administration of guanethidine for 6 weeks to 26 °C acclimated rats (5 mg every third day) resulted in an increased sensitivity to noradrenaline. The observed rise in metabolic response to a single dose of noradrenaline (2 mg/kg, intramuscular) was similar in these guanethidine-treated rats to the hone observed in cold-acclimated rats; however, their cold resistance was not changed. It is concluded that the increased sensitivity to noradrenaline of the chronically cold-exposed rats is not sufficient by itself to explain even in part their increased resistance to cold.Keywords
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