Detection ofAPCMutations in Fecal DNA from Patients with Colorectal Tumors
- 31 January 2002
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 346 (5) , 311-320
- https://doi.org/10.1056/nejmoa012294
Abstract
Noninvasive methods for detecting colorectal tumors have the potential to reduce morbidity and mortality from this disease. The mutations in the adenomatous polyposis coli (APC) gene that initiate colorectal tumors theoretically provide an optimal marker for detecting colorectal tumors. The purpose of our study was to determine the feasibility of detecting APC mutations in fecal DNA with the use of newly developed methods.Keywords
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