The Role of Leukocyte Depletion in Reducing Injury to Myocardium and Lung During Cardiopulmonary Bypass
- 1 July 1995
- journal article
- clinical trial
- Published by Wolters Kluwer Health in Asaio Journal
- Vol. 41 (3) , M291-M294
- https://doi.org/10.1097/00002480-199507000-00015
Abstract
Activated leukocytes and oxygen free radicals have been implicated in the pathogenesis of heart and lung injury after reperfusion and during cardiopulmonary bypass. This study was designed to determine whether leukocyte depletion prevents injury to the heart and lung during cardiopulmonary bypass. Twenty-eight open heart surgeries were performed in this study. In Group F, leukocyte depletion was performed with an LG-6 arterial line filter after aortic declamp (n = 14). Leukocyte depletion was not performed during cardiopulmonary bypass in Group C (n = 14). Thereafter, cardiac and lung function were assessed in the 24 hr after reperfusion. The total catecholamine dose used for 24 hr after reperfusion (r) was 61.9 ± 13.4 in Group C and 43.9 ± 19.2 in Group F (pKeywords
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