Comparison of Bactericidal Activity of Five Antibiotics against Staphylococcus aureus

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Abstract
Ten volunteers were given each of five antibiotics, sequentially, until steady state was reached. Peak and trough sera were then drawn, and bactericidal titers were determined to two different isolates of Staphylococcus aureus, both sensitive in vitro to all antibiotics tested. The antibiotics were cephalexin, trimethoprim/sulfamethoxazole (TMP/SMZ), clindamycin, dicloxacillin, and ciprofloxacin. Mean peak serum bactericidal titers (SBT)were significantly higher for cephalexin than for dicloxacillin, ciprofloxacin,and TMP/SMZ(P < .05).The difference between cephalexin and clindamycin did not achieve statistical significance. Dicloxacillin, clindamycin, and ciprofloxacin were not statistically different from each other. Mean SBT for TMP/SMZ was 1:2. This was statistically significant compared with each of the other antibiotics.