Pre- and postcapillary resistance in the dog forelimb

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Abstract
Experiments were performed on the completely isolated forelimb of the dog in which arterial pressure was reduced while capillary pressure was kept constant. This was done by the isogravimetric technique. In 26 experiments on 10 preparations venous resistance decreased as arterial pressure was reduced. The behavior of the forellmb vessels contrasts with that of the hlndlimb. In the whole hindllmb venous resistance remains constant during the isogravimetric procedure, whereas in the skinned hindllmb venous resistance increases as arterial pressure is reduced. Since the fore-limb contains relatively more cutaneous tissue than does the hindlimb, the results may be interpreted to mean that venous vessels in the cutaneous tissue respond only in a passive manner to changes in arterial and venous pressure. There is no evidence of an arteriovenous reflex in the skin circulation. These experiments also failed to show any evidence for autoregulation in the forelimb vessels.

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