Control of Thyroglobulin Synthesis and Secretion

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Abstract
(Second of Two Parts)Circulating ThyroglobulinFor several decades, thyroglobulin was thought to be confined to the thyroid gland. This view can no longer be defended since thyroglobulin has unquestionably been demonstrated in the peripheral circulation of man.154 , 155 In this part of our review we attempt to summarize the state of the art regarding thyroglobulin. For the sake of clarity, the subject is discussed as follows: methodologic developments that have made possible measurement of thyroglobulin in the circulation, evidence supporting the concept that thyroglobulin is a normal secretory product of the thyroid gland, thyroglobulin levels in disease states of the . . .