Synthesis of acylamino acid esters of nucleoside 5′-phosphates and their investigation with PMR and CD spectra
Open Access
- 1 January 1977
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 4 (7) , 2223-2234
- https://doi.org/10.1093/nar/4.7.2223
Abstract
The acylemino acid esters of nucleoside 5′-phosphates are synthesized via condensation of N-(N'-acylaainoacyl)imidazoles with nucleoside 5′-phosphates. The PMR and CD spectra of the esters obtained are studied. The 3′-isomers of the substances under study are observed to have a shift in the conformational N=S equilibrium of the carbobydrate moiety in favour of the S-form as compared to the initial nucleosides and their 2′-acyl esters.Keywords
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