SUCCESSFUL TREATMENT OF A PATIENT WITH PERIOPERATIVE MASSIVE PULMONARY-EMBOLISM AND CARDIAC-ARREST WITH RECOMBINANT TISSUE-TYPE PLASMINOGEN-ACTIVATOR (RT-PA)
- 1 January 1990
- journal article
- research article
- Vol. 39 (1) , 50-52
Abstract
We report a patient with massive perioperative pulmonary embolism (stage IV) and cardiac arrest who was successfully treated with recombinant tissue plasminogen activator (rt-PA). Thrombolytic therapy was started with 25 mg rt-Pa over 15 min followed by another 25 mg over 45 min. During the next 5 h 50 mg were infused, and thereafter an additional 50 mg over 24 h. No major alterations in the plasmatic coagulation profile were noted. With the exception of moderate blood loss from one puncture site, no further bleeding complications occurred. The relevance of this new thrombolytic agent in the perioperative management of acute, life-threatening pulmonary embolism is discussed.This publication has 4 references indexed in Scilit:
- Recombinant tissue-type plasminogen activator in canine embolic pulmonary hypertension. Effects of bolus versus short-term administration on dynamics of thrombolysis and on pulmonary vascular pressure-flow characteristics.Circulation, 1989
- Intravenous and intrapulmonary recombinant tissue-type plasminogen activator in the treatment of acute massive pulmonary embolism.Circulation, 1988
- ACUTE PULMONARY EMBOLISM TREATED WITH TISSUE PLASMINOGEN ACTIVATORThe Lancet, 1986
- 1ST RESULTS OF EMERGENCY TREATMENT IN MASSIVE FULMINANT LUNG EMBOLISM BY MEANS OF A RAPIDLY INJECTED STREPTOKINASE IN A HIGH INITIAL DOSE1980