Tritiated peptides. Part 8. Synthesis of [3,5-3H2-Tyr2]-, [4-3H-Phe7]-, and [3,5-3H2-Tyr23]-human corticotrophin
- 1 January 1980
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 2,p. 462-465
- https://doi.org/10.1039/p19800000462
Abstract
Syntheses are described of human corticotrophin nonatriacontapeptides separately labelled with tritium in the tyrosine residues at positions 2 and 23 and in the phenylalanine residue at position 7 at specific radioactivities of 49, 25, and 31 Ci mmol–1 respectively. Labelling was by reductive deiodination of protected precursors. Evidence for the integrity of the final products is provided by amino-acid analysis, column chromatography, and bioassay, supported by chemical and enzymic analytical data.This publication has 2 references indexed in Scilit:
- Adrenocorticotropin. 51. Synthesis and properties of analogs of the human hormone with tyrosine residues replaced by 3,5-diiodotyrosineJournal of the American Chemical Society, 1977
- METABOLISM IN VITRO OF TRITIATED ADRENOCORTICOTROPIC HORMONECanadian Journal of Biochemistry, 1965