Boolean implication networks derived from large scale, whole genome microarray datasets
Open Access
- 30 October 2008
- journal article
- research article
- Published by Springer Nature in Genome Biology
- Vol. 9 (10) , 1-17
- https://doi.org/10.1186/gb-2008-9-10-r157
Abstract
We describe a method for extracting Boolean implications (if-then relationships) in very large amounts of gene expression microarray data. A meta-analysis of data from thousands of microarrays for humans, mice, and fruit flies finds millions of implication relationships between genes that would be missed by other methods. These relationships capture gender differences, tissue differences, development, and differentiation. New relationships are discovered that are preserved across all three species.Keywords
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