Characterization of the Antihistamines Tripelennamine, Methapyrilene, and Thenyldiamine and Their N-Oxides by Thermospray Mass Spectrometry

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Abstract
This study describes an investigation of the thermospray (TS) mass spectrometric analysis of tripelennamine, methapyrilene, thenyldiamine, and their N-oxide derivatives. These compounds were analyzed by direct injection TS mass spectrometry in the column bypass mode and with 0.1M ammonium acetate/methanol (80:20, v/v) as the mobile phase. Typically, the parent antihistamines produced only [MH]+ ions under these conditions. The N-oxides provided strong [MH]+ ions and multiple fragment ions. A scheme to explain the fragmentation patterns is proposed.