CONTROL OF INTRACTABLE ATONIC POSTPARTUM HEMORRHAGE BY 15-METHYL PROSTAGLANDIN-F2-ALPHA

  • 1 January 1981
    • journal article
    • research article
    • Vol. 58  (3) , 327-330
Abstract
Severe intractable atonic postpartum hemorrhage can be treated by uterine packing or surgical techniques. Certain prostaglandins [PG] possess properties of potential value for the control of postpartum uterine atony. 15-Methyl PGF2.alpha. (250 .mu.g) was given i.m. to 16 subjects for whom a uterine pack or operative management was the only other alternative. Fifteen patients responded satisfactorily following a mean of 1.75 injections (437.5 .mu.g); only 1 patient required hysterectomy. The latter had a case of severe intrauterine infection. The incidence of side effects was very low. The use of i.m. administered 15-methyl PGF2.alpha. in uncontrollable atonic postpartum hemorrhage appears to be a valuable lifesaving medical tool in critical cases.

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