Allergic Reactions to Isosulfan Blue in Sentinel Lymph Node Mapping

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Abstract
Background: Sentinel lymph node (SLN) biopsy is often used in the assessment of lymph node status in melanoma and early stage breast cancer. With the rapidly increasing use of the technique, we can now better characterize and assess the rate of adverse reactions to the dye. Methods: A retrospective review of all patients undergoing SLN mapping at the Columbia‐Presbyterian Breast Center were identified from June 2000 to July 2002. All patients who experienced allergic reactions were documented and records examined. Results: In total, three out of 351 patients had allergic complications from the procedure. All three patients developed “blue hives” after injection with isosulfan blue. The incidence at our Breast Center was 0.9%. All were treated with intravenous corticosteroids and diphenhydramine and recovered within twenty‐four hours. Conclusions: The increasing utilization of the sentinel lymph node technique will make these complications more common. A high index of suspicion and appropriate clinical management are recommended to minimize the potential morbidity of these reactions.