Capsaicin enhances allergic contact dermatitis in the guinea pig
- 1 January 1991
- journal article
- Published by Wiley in Contact Dermatitis
- Vol. 24 (1) , 30-34
- https://doi.org/10.1111/j.1600-0536.1991.tb01626.x
Abstract
Guinea pigs were sensitized to dinitrochlorobenzene (DNCB) by the intracutaneous route and challenged epicutaneously on the flanks. The intensity of the allergic contact dermatitis was evaluated by inspection and palpation as well as by wet weight determination. With the purpose of diminishing tissue neuropeptides, and substance P in particular, the animals were treated with capsaicin either between induction and challenge, or before sensitization. In comparison with controls, the contact dermatitis was enhanced in both groups of animals treated with capsaicin.Keywords
This publication has 11 references indexed in Scilit:
- Neuroimmune interactions in the airways: Implications for asthma, allergy, and other inflammatory airway diseasesBrain, Behavior, and Immunity, 1988
- Some neuropeptides as modulators of experimental contact allergyContact Dermatitis, 1988
- The differential effect with time of neuropeptides on the proliferative responses of murine Peyer's patch and splenic lymphocytesBrain, Behavior, and Immunity, 1987
- The effect of capsaicin on some experimental inflammations in human skinActa Dermato-Venereologica, 1986
- Capsaicin treatment decreases tissue levels of neurokinin A‐like immunoreactivity in the guinea pigActa Physiologica Scandinavica, 1985
- The immune system as a sensory organ.The Journal of Immunology, 1984
- What do the immune system and the brain know about each other?Immunology Today, 1983
- Capsaicin: hot new pharmacological toolTrends in Pharmacological Sciences, 1983
- Effects of capsaicin applied locally to adult peripheral nerve. II. Anatomy and enzyme and peptide chemistry of peripheral nerve and spinal cordPain, 1981
- Allergic contact dermatitis of the mouse earActa Dermato-Venereologica, 1981