ORIGIN OF THE ANDROSTERONE IN THE URINE OF WOMEN

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Abstract
After menopause, urinary 17-ketosteroids (17KS) are reduced, with most of the reduction occurring in the androsterone and etiocholanolone fractions. After menopause, castration does not alter the 17KS excretion pattern, but castration of the sexually active woman reduces the androsterone and etiocholanolone fractions (single case). The increased urinary 17KS in women with arrhenoblastoma (5 cases) are due to increased androsterone and etiocholanolone fractions. Since, in males, much of the injd. testosterone can be recovered as etiocholanolone and androsterone, the authors suggest that the ovaries may produce an androgenic 17KS-precursor, possibly testosterone.