Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine
- 1 March 2008
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry
- Vol. 16 (5) , 2148-2155
- https://doi.org/10.1016/j.bmc.2007.11.082
Abstract
No abstract availableKeywords
This publication has 12 references indexed in Scilit:
- A rapid DNA hybridization assay for the evaluation of antiviral compounds against Epstein-Barr virusJournal of Virological Methods, 2007
- Fluoroanalogues of Anti-Cytomegalovirus Agent Cyclopropavir: Synthesis and Antiviral Activity of (E)- and (Z)-9-{[2,2-Bis(Hydroxymethyl)-3-Fluorocyclopropylidene]Methyl}-Adenines and GuaninesNucleosides, Nucleotides and Nucleic Acids, 2007
- 9-{[3-Fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and Antiviral Activity of All StereoisomersJournal of Medicinal Chemistry, 2006
- In Vitro Activity and Mechanism of Action of Methylenecyclopropane Analogs of Nucleosides against Herpesvirus ReplicationAntimicrobial Agents and Chemotherapy, 2005
- Enhancement of antiviral activity against hepatitis C virus in vitro by interferon combination therapyAntiviral Research, 2005
- Nucleotides and Pronucleotides of 2,2-Bis(hydroxymethyl)methylenecyclopropane Analogues of Purine Nucleosides: Synthesis and Antiviral ActivityJournal of Medicinal Chemistry, 2004
- Oral Activity of a Methylenecyclopropane Analog, Cyclopropavir, in Animal Models for Cytomegalovirus InfectionsAntimicrobial Agents and Chemotherapy, 2004
- (Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a New Class of Methylenecyclopropane Analogues of Nucleosides: Synthesis and Antiviral ActivityJournal of Medicinal Chemistry, 2004
- Synthesis and Antiviral Activity of (Z)- and (E)-2,2-[Bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: Second-Generation Methylenecyclopropane Analogues of NucleosidesJournal of Medicinal Chemistry, 2003
- Efficient Initiation of HCV RNA Replication in Cell CultureScience, 2000