ANGIOTENSIN-CONVERTING ENZYME IN DIABETES-MELLITUS DEPENDENCE ON METABOLIC ABERRATION

  • 1 January 1983
    • journal article
    • research article
    • Vol. 9  (3) , 179-182
Abstract
Serum angiotensin-converting enzyme (s-ACE) was measured in 56 diabetic outpatients and in 6 juvenile insulin-dependent diabetics who developed mild to moderate ketosis after insulin withdrawal. In the outpatients mean s-ACE was increased by 24% compared to healthy controls. However, development of ketosis resulted in significant reduction of s-ACE from 29.2 .+-. 1.6 U/ml (.+-. SEM[standard error of the mean]) to 23.1 .+-. 1.9 U/ml (P < 0.05). In addition , a clearcut inverse correlation was observed between blood 3-hydroxybutyrate rise and s-ACE decrement (P < 0.001). The reduction observed may be mediated through the metabolic acidosis.